News & Research

The Siggy Blog

Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.

Showing Failed Antidepressants 1 article

What Is Treatment-Resistant Depression? Signs You Have It and What to Do Next

Treatment-resistant depression (TRD) is defined as depression that doesn't improve after two or more adequate antidepressant trials. About 30% of people with major depression meet this definition. Here is what comes next.

June 18, 2026TRD SignsFailed AntidepressantsEsketamine TreatmentAntidepressant ResistanceDepression Next Steps