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The Siggy Blog

Expert articles on medications, conditions, and the future of mental healthcare, from the team building it.

First-Line vs Second-Line Antidepressants: How Doctors Choose Your Next Step

Not all antidepressants are chosen the same way. Learn how doctors select first-line SSRIs and when second-line options become the right next step for depression treatment.

June 17, 2026Antidepressant SelectionFirst-Line AntidepressantsDepression PharmacotherapySSRI GuidelinesTreatment Response